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KMID : 0377519910160010091
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Chung-Ang Journal of Medicine
1991 Volume.16 No. 1 p.91 ~ p.104
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A Study on Superoxide Radical Formation, Catalase and Superoxide Dismutase Activities in Experimental Cerebral Infarction
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Abstract
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To observe the role of oxygen free radical and enzymatic scavengers in cerebral ischemia, an
.r: infarction model was made using transorbital occlusion of the middle cerebral artery in cats.´ The
sic in
x lianges of the superoxide radical production and the activities of superoxide dismutase and catalase
were measured.
The results were as follows.
nd
~r 1: The infarction of the left middle cerebral artery (MCA) territory was identified with intracar-
ro
14 diac perfusion of a TTC solution after transorbital occlusion.
in ta>
2. The superoxide radical activities after occlusion of the left MCA were not changed in all groups ur-
except for the decrease in 6 hours group of the right side compared to the control group (p<0.05). ev.
3. The Mn-superoxide dismutase activities of the left side in the 12 hours group were significant-
ly higher than those of the right side (p<0.01) and those in the control group (p<0.05).
R.
4. The Cu, Zn-superoxide dismutase activities of the left side in the 3 hours group after occlusion -a
of the left MCA were significantly higher than those in the control group (p<0.05).
its
im 5. The catalase activities of the left side of in the 3 hours, 6 hours and 12 hours groups after
occlusion of the left MCA were significantly higher than those of the right side (p<0.05).
6. The catalases activitie of the left side in the 12 hours group after occlusion of the left MCA id were significantly higher than those in the control group (p<0.05).
of The authors suggest that the enzymatic scavangers such as Mn-SOD, Cu, Zu-SOD and catalase
increased in the infarcted brain, which means an involvement of free radicals in cerebral infaraction.
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